Responding to the rofecoxib withdrawal crisis: A new model for notifying patients at risk and their health care providers

Background: We decided to inform our patients of the withdrawal of rofecoxib, one of the largest drug withdrawals in United States history, and instruct them to contact their providers for guidance. Objective: To identify and inform patients and providers affected by the rofecoxib withdrawal. Design: Descriptive observational study. Setting: Tertiary care center with an electronic medical record (EMR) system. Patients: Patients with an active rofecoxib prescription within the EMR. Intervention: Existing information technology and traditional communication resources were used to automate the identifying and notifying of patients and providers and to deactivate rofecoxib prescriptions in the EMR. Measurements: characteristics of patients receiving rofecoxib at our institution, details of their prescription and provider, number of EMR alerts, and medication discontinuations. Results: The 11699 patients with a rofecoxib prescription in our practice were sent notifications within 24 hours of the withdrawal. Limitations: we did not directly measure the effect of our notification on patients or providers. Conclusions: information technology enabled our institution to rapidly identify and notify individual patients and their providers about an important drug withdrawal. The methods modeled a feasible way for health care organizations with EMRs to participate in notification processes that may be applicable in a variety of situations.