Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

被引：1186

作者：

Cinatl, J ^{[1
]}

Morgenstern, B ^{[1
]}

Bauer, G ^{[1
]}

Chandra, P ^{[1
]}

Rabenau, H ^{[1
]}

Doerr, HW ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Sch Med, Inst Med Virol, D-60596 Frankfurt, Germany

来源：

LANCET | 2003年 / 361卷 / 9374期

关键词：

D O I：

10.1016/S0140-6736(03)13615-X

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus Infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical Isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.

引用

页码：2045 / 2046

页数：2

共 5 条

[1]

Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area [J].

Booth, CM ;

Matukas, LM ;

Tomlinson, GA ;

Rachlis, AR ;

Rose, DB ;

Dwosh, HA ;

Walmsley, SL ;

Mazzulli, T ;

Avendano, M ;

Derkach, P ;

Ephtimios, IE ;

Kitai, I ;

Mederski, BD ;

Shadowitz, SB ;

Gold, WL ;

Hawryluck, LA ;

Rea, E ;

Chenkin, JS ;

Cescon, DW ;

Poutanen, SM ;

Detsky, AS .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (21) :2801-2809

[2]

Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses [J].

Crance, JM ;

Scaramozzino, N ;

Jouan, A ;

Garin, D .

ANTIVIRAL RESEARCH, 2003, 58 (01) :73-79

[3]

Identification of a novel coronavirus in patients with severe acute respiratory syndrome [J].

Drosten, C ;

Günther, S ;

Preiser, W ;

van der Werf, S ;

Brodt, HR ;

Becker, S ;

Rabenau, H ;

Panning, M ;

Kolesnikova, L ;

Fouchier, RAM ;

Berger, A ;

Burguière, AM ;

Cinatl, J ;

Eickmann, M ;

Escriou, N ;

Grywna, K ;

Kramme, S ;

Manuguerra, JC ;

Müller, S ;

Rickerts, V ;

Stürmer, M ;

Vieth, S ;

Klenk, HD ;

Osterhaus, ADME ;

Schmitz, H ;

Doerr, HW .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) :1967-1976

[4]

Induction of inducible nitric oxide synthase expression by 18β-glycyrrhetinic acid in macrophages [J].

Jeong, HG ;

Kim, JY .

FEBS LETTERS, 2002, 513 (2-3) :208-212

[5]

Inhibition of Japanese encephalitis virus infection by nitric oxide: Antiviral effect of nitric oxide on RNA virus replication [J].

Lin, YL ;

Huang, YL ;

Ma, SH ;

Yeh, CT ;

Chiou, SY ;

Chen, LK ;

Liao, CL .

JOURNAL OF VIROLOGY, 1997, 71 (07) :5227-5235

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