Use of a polyclonal antibody for the determination of the prognostic value of c-erbB-2 protein over-expression in human breast cancer

被引:5
作者
Terrier, P
Mouriesse, H
Loridon, B
Gotteland, M
MayLevin, F
Delarue, JC
机构
[1] INST GUSTAVE ROUSSY,DEPT MED STAT,F-94805 VILLEJUIF,FRANCE
[2] INST GUSTAVE ROUSSY,DEPT MED,F-94805 VILLEJUIF,FRANCE
[3] INST GUSTAVE ROUSSY,DEPT BIOL CHEM,F-94805 VILLEJUIF,FRANCE
[4] INST RECH SCI CANC,VILLEJUIF,FRANCE
关键词
D O I
10.3109/02841869609098475
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A rabbit-specific polyclonal antibody was obtained raised to a synthetic peptide corresponding to the 1238-1255 C-terminal predicted sequence of the c-erbB-2 protein. This antibody was used in an immunohistochemical procedure to detect the c-erbB-2 protein on a series of 88 paraffin-embedded human breast carcinomas. In 14/88 cases (16%) the c-erbB-2 protein was found to be overexpressed (immunohistochemical score > 1) with a good concordance with the previously determined mRNA level (79/88 cases: 90%). Prognostic significance of c-erbB-2 protein overexpression as detected by immunohistochemistry was tested by the log-rank test. The relative risk of relapse is higher for patients with an immunohistochemical score > 1 (p = 0.00002). In a multivariate analysis the c-erbB-2 immunohistochemical score was the only powerful parameter (p < 1 . 10(-3)). In conclusion, this antibody seems to be a valuable tool in estimating the c-erbB-2 protein regarded in our series as a parameter able to identify a subgroup of operable breast cancer patients with a high risk of relapse.
引用
收藏
页码:23 / 30
页数:8
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