Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx

被引：42

作者：

Peppelenbosch, MP

Tertoolen, LGJ

deVriesSmits, AMM

Qiu, RG

MRabet, L

Symons, MH

deLaat, SW

Bos, JL

机构：

[1] UNIV UTRECHT,PHYSIOL CHEM LAB,3584 CG UTRECHT,NETHERLANDS

[2] NETHERLANDS INST DEV BIOL,HUBRECHT LAB,3584 CT UTRECHT,NETHERLANDS

[3] ONYX PHARMACEUT,RICHMOND,CA 94806

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1996年 / 271卷 / 14期

关键词：

D O I：

10.1074/jbc.271.14.7883

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report that expressing interfering mutants of the small Ras-related GTPase Rac, using either recombinant vaccinia virus or stable DNA transfection, eliminates epidermal growth factor-induced Ca2+ signaling, without affecting Ca2+ mobilization or influx from G protein-coupled receptors. Platelet-derived growth factor-dependent Ca2+ influx, however, is only partly sensitive to dominant negative Rac proteins. Thus, whereas epidermal growth factor-induced Ca2+ influx is completely mediated by Rac proteins, platelet-derived growth factor-induced Ca2+ influx involves Rac-dependent and -independent signaling pathways.

引用

收藏

页码：7883 / 7886

页数：4

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