Antiallergic activities of rabdosiin and its related compounds: Chemical and biochemical evaluations

被引：75

作者：

Ito, H

Miyazaki, T

Ono, M

Sakurai, H

机构：

[1] Nagase & Co Ltd, Ctr Res & Dev, Kobe, Hyogo 6512241, Japan

[2] Kyoto Pharmaceut Univ, Dept Analyt Chem & Bioinorgan Chem, Yamashina Ku, Kyoto 6078841, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 07期

关键词：

rabdosiin; anti-allergic activity; ESR-spin trapping method; hyaluronidase; beta-hexosaminidase;

D O I：

10.1016/S0968-0896(98)00063-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effects of caffeic acid-containing compounds such as chlorogenic acid, rosmarinic acid and rabdosiin on anti-allergic activities involving active oxygens scavenging activity as well as inhibitory activities of hyaluronidase and beta-hexosaminidase release. Rabdosiin exhibited the highest hyaluronidase-inhibitory activity and scavenging activities against active oxygens species such as superoxide anion radicals and hydroxyl radicals among the tested compounds. Both rabdosiin and caffeic acid inhibited beta-hexosaminidase release from cultured cells more than 90% at 2 mM. The inhibition by rosmarinic acid and chlorogenic acid were weaker than that of rabdosiin. From these results, rabdosiin has been proposed to possess anti-allergic activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1051 / 1056

页数：6

共 37 条

[1]

AGATA I, 1988, CHEM PHARM BULL, V36, P3223

[2] TANNINS IN LABIATAE PLANTS .2. A TETRAMERIC DERIVATIVE OF CAFFEIC ACID FROM RABDOSIA-JAPONICA [J].