Topiramate increases cerebral GABA in healthy humans

被引：92

作者：

Kuzniecky, R

Hetherington, H

Ho, S

Pan, J

Martin, R

Gilliam, F

Hugg, J

Faught, E

机构：

[1] Univ Alabama, Dept Neurol, UAB Epilepsy Ctr, Birmingham, AL 35294 USA

[2] Univ Alabama, Ctr Nucl Imaging Res, Birmingham, AL 35294 USA

来源：

NEUROLOGY | 1998年 / 51卷 / 02期

关键词：

D O I：

10.1212/WNL.51.2.627

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Topiramate (TOP) is a novel anticonvulsant drug with multiple mechanisms of action used in the treatment of epilepsy. Measurements of cerebral GABA were obtained in six controls using H-1 MRS at baseline and at 3 and 6 hours following the administration of 3 mg/kg of TOP. Brain GABA concentrations rose by 72% at 3 hours and by 64% at 6 hours compared with baseline (p < 0.004). This study demonstrates that TOP significantly increases human cerebral GABA concentrations in healthy individuals.

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页码：627 / 629

页数：3

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