The role of natural killer cells in tumor control - effectors and regulators of adaptive immunity

被引：70

作者：

Wallace, ME ^{[1
]}

Smyth, MJ ^{[1
]}

机构：

[1] Peter MacCallum Canc Ctr, Canc Immunol Program, Sir Donald & Lady Trescowthick Labs, Melbourne, Vic 8006, Australia

来源：

SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 2005年 / 27卷 / 01期

关键词：

immunotherapy; immunosurveillance; cytokine; cytotoxicity; dendritic cells;

D O I：

10.1007/s00281-004-0195-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are the primary effector cells of the innate immune system and have a well-established role in tumor rejection in a variety of spontaneous and induced cancer models. NK cell function is regulated by a complex balance of inhibitory and activating signals that allow them to selectively target and kill cells that display an abnormal pattern of cell surface molecules, while leaving normal healthy cells unharmed. In this review we discuss NK cell function, the role of NK cells in cancer therapies, the emerging concept of bi-directional cross-talk between NK cells and dendritic cells, and the implications of these interactions for tumor immunotherapy.

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页码：49 / 64

页数：16

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