Thrombin interactions

被引：122

作者：

Di Cera, E ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA

来源：

CHEST | 2003年 / 124卷 / 03期

关键词：

anticoagulants; blood coagulation; thrombin; thrombin receptors;

D O I：

10.1378/chest.124.3_suppl.11S

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

After generation from prothrombin, thrombin plays multiple roles in the blood coagulation cascade that are mediated by interaction with a number of physiologic substrates, effectors, and inhibitors. Structural and mutagenesis studies have helped unravel the molecular basis of thrombin interactions in the context of both well-established and emerging new roles of the enzyme. The functional versatility of thrombin owes much to its evolutionary origin and results from structural determinants and mechanisms that can be exploited by pharmacologic intervention.

引用

页码：11S / 17S

页数：7

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