The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role

被引：220

作者：

Abdulamir, Ahmed S. ^{[1
]}

Hafidh, Rand R. ^{[1
]}

Abu Bakar, Fatimah ^{[1
]}

机构：

[1] Univ Putra Malaysia, Inst Biosci, Serdang 43400, Selangor, Malaysia

来源：

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2011年 / 30卷

关键词：

INFLAMMATORY-BOWEL-DISEASE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GALLOLYTICUS SUBSP MACEDONICUS; NF-KAPPA-B; BOVIS BACTEREMIA; COLON-CANCER; CROHNS-DISEASE; INFECTIVE ENDOCARDITIS; GASTRIC-CANCER; INCREASED RISK;

D O I：

10.1186/1756-9966-30-11

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Streptococcus bovis (S. bovis) bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80% of patients with S. bovis/gallolyticus bacteremia have concomitant colorectal tumors. Colonic neoplasia may arise years after the presentation of bacteremia or infectious endocarditis of S. bovis/gallolyticus. The presence of S. bovis/gallolyticus bacteremia and/or endocarditis is also related to the presence of villous or tubular-villous adenomas in the large intestine. In addition, serological relationship of S. gallolyticus with colorectal tumors and direct colonization of S. gallolyticus in tissues of colorectal tumors were found. However, this association is still under controversy and has long been underestimated. Moreover, the etiological versus non-etiological nature of this associationis not settled yet. Therefore, by covering the most of up to date studies, this review attempts to clarify the nature and the core of S. bovis/gallolyicus association with colorectal tumors and analyze the possible underlying mechanisms.

引用

页数：13

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