A supramolecular approach to multivalent target-specific MRI contrast agents for angiogenesis

被引:45
作者
Dirksen, A
Langereis, S
de Waal, BFM
van Genderen, MHP
Hackeng, TM
Meijer, EW
机构
[1] Eindhoven Univ Technol, Lab Macromol & Organ Chem, NL-5600 MB Eindhoven, Netherlands
[2] Univ Maastricht, CARIM, NL-6200 MD Maastricht, Netherlands
关键词
D O I
10.1039/b502347e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The synthesis of a cyclic peptide-Gd(III)DTPA molecule equipped with biotin is presented, yielding a well-defined multivalent MRI contrast agent after its coupling to avidin.
引用
收藏
页码:2811 / 2813
页数:3
相关论文
共 21 条
[1]  
Anderson SA, 2000, MAGNET RESON MED, V44, P433, DOI 10.1002/1522-2594(200009)44:3<433::AID-MRM14>3.0.CO
[2]  
2-9
[3]   Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].
Caravan, P ;
Ellison, JJ ;
McMurry, TJ ;
Lauffer, RB .
CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352
[4]  
Curnis F, 2002, CANCER RES, V62, P867
[5]   SYNTHESIS OF PROTEINS BY NATIVE CHEMICAL LIGATION [J].
DAWSON, PE ;
MUIR, TW ;
CLARKLEWIS, I ;
KENT, SBH .
SCIENCE, 1994, 266 (5186) :776-779
[6]   Design and synthesis of a bimodal target-specific contrast agent for angiogenesis [J].
Dirksen, A ;
Langereis, S ;
de Waal, BFM ;
van Genderen, MHP ;
Meijer, EW ;
de Lussanet, QG ;
Hackeng, TM .
ORGANIC LETTERS, 2004, 6 (26) :4857-4860
[7]  
GREEN NM, 1990, METHOD ENZYMOL, V184, P51
[9]   Protein synthesis by native chemical ligation: Expanded scope by using straightforward methodology [J].
Hackeng, TM ;
Griffin, JH ;
Dawson, PE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (18) :10068-10073
[10]  
Jacques V, 2002, TOP CURR CHEM, V221, P123