Neural transplantation therapies for Parkinson's and Huntington's diseases

被引:9
作者
Barker, RA
Rosser, AE
机构
[1] Addenbrookes Hosp, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England
[2] Addenbrookes Hosp, Dept Neurol, Cambridge CB2 2PY, England
[3] Cardiff Univ, Sch Biosci, Brain Repair Grp, Cardiff CF10 3US, S Glam, Wales
基金
英国医学研究理事会;
关键词
D O I
10.1016/S1359-6446(01)01775-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Parkinson's and Huntington's diseases are progressive neurodegenerative disorders of the central nervous system for which symptomatic but not curative therapies are available. Therapeutic strategies have been developed to try and repair the brain in these conditions, including the use of grafts of foetal neural tissue. Here, we consider the merits of this approach and discuss the extent to which neural transplantation has successfully been translated into clinical studies for these diseases.
引用
收藏
页码:575 / 582
页数:8
相关论文
共 63 条
[1]  
ANNETT LE, 1994, FUNCTIONAL NEURAL TR, P71
[2]  
[Anonymous], [No title captured]
[3]   Neural stem cells: From cell biology to cell replacement [J].
Armstrong, RJE ;
Svendsen, CN .
CELL TRANSPLANTATION, 2000, 9 (02) :139-152
[4]   Motor and cognitive improvements in patients with Huntington's disease after neural transplantation [J].
Bachoud-Lévi, A ;
Rémy, P ;
Nguyen, JP ;
Brugières, P ;
Lefaucheur, JP ;
Bourdet, C ;
Baudic, S ;
Gaura, V ;
Maison, P ;
Haddad, B ;
Boissé, MF ;
Grandmougin, T ;
Jény, R ;
Bartolomeo, P ;
Dalla Barba, G ;
Degos, JD ;
Lisovoski, F ;
Ergis, AM ;
Pailhous, E ;
Cesaro, P ;
Hantraye, P ;
Peschanski, M .
LANCET, 2000, 356 (9246) :1975-1979
[5]   Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease [J].
Bachoud-Lévi, AC ;
Bourdet, C ;
Brugières, P ;
Nguyen, JP ;
Grandmougin, T ;
Haddad, B ;
Jény, R ;
Bartolomeo, P ;
Boissé, MF ;
Dalla Barba, G ;
Degos, JD ;
Ergis, AM ;
Lefaucheur, JP ;
Lisovoski, F ;
Pailhous, E ;
Rémy, P ;
Palfi, S ;
Defer, GL ;
Cesaro, P ;
Hantraye, P ;
Peschanski, M .
EXPERIMENTAL NEUROLOGY, 2000, 161 (01) :194-202
[6]  
Barker R, 1993, Rev Neurosci, V4, P113
[7]  
Barker R. A., 1999, NEUROPSY REHABIL MOD
[8]   Porcine neural xenografts: what are the issues? [J].
Barker, RA .
NEURAL TRANSPLANTATION IN NEURODEGENERATIVE DISEASE: CURRENT STATUS AND NEW DIRECTIONS, 2000, 231 :184-196
[9]   Neural tissue xenotransplantation: What is needed prior to clinical trials in Parkinson's disease? [J].
Barker, RA ;
Kendall, AL ;
Widner, H .
CELL TRANSPLANTATION, 2000, 9 (02) :235-246
[10]  
BARKER RA, 1999, NEUROMETHODS CELL TI, P195