Novel physiological function of fructooligosaccharides

被引:32
作者
Tokunaga, T [1 ]
机构
[1] Meiji Seika Kaisha Ltd, Hlth & Biosci Labs, Sakado, Saitama 3500289, Japan
关键词
fructooligosaccharides; prebiotics; Bifidobacteria; short chain fatty acids; isoflavone;
D O I
10.1002/biof.552210117
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two key properties of short chain fructooligosacchari des (sc-FOS) which lead to physiological functions are indigestibility in the small intestine and fermentability in the colon. Sc-FOS is converted into short chain fatty acids (SCFAs) by intestinal bacteria in the colon and absorbed. Through the metabolic pathway, sc-FOS improves gastrointestinal (GI) condition such as relief from constipation, formation of preferable intestinal microflora and intestinal immunomodulation those are known as prebiotics' function. Besides improvement of GI condition, dietary sc-FOS influences on calcium and magnesium absorption in the colon. A major mineral absorption site is the small intestine, but the colon also works as a Ca and Mg absorption site with an aid of SCFAs made from sc-FOS. Furthermore dietary sc-FOS influences on bioavailability of soy-isoflavones. Plasma and urinal concentration of Genistein and Daidzein, aglycones of Daidzin and Genistin, are higher in the rat fed with sc-FOS than the control rat. An additive effect of dietary isoflavone and sc-FOS was observed on the bone mineral density in OVX mice and moreover sc-FOS increased ceacal beta-glycosidase activity and equol production. These results suggest that FOS increase the bioavailability of isoflavones.
引用
收藏
页码:89 / 94
页数:6
相关论文
共 15 条
[1]  
[Anonymous], 1991, Bifidobacteria and Microflora
[2]  
HIDAKA H, 1988, AGR BIOL CHEM TOKYO, V52, P1181
[3]   Dietary fructooligosaccharides induce immunoregulation of intestinal IgA secretion by murine Peyer's patch cells [J].
Hosono, A ;
Ozawa, A ;
Kato, R ;
Ohnishi, Y ;
Nakanishi, Y ;
Kimura, T ;
Nakamura, R .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2003, 67 (04) :758-764
[4]  
HOSOYA N, 1988, J CLIN BIOCHEM NUTR, V5, P67
[5]  
KAMEOKA S, 1986, JPN J CLIN NUTR, V68, P823
[6]  
MITSUOKA T, 1987, NAHRUNG, V31, P427
[7]   Dietary fructooligosaccharides prevent a reduction of cortical and trabecular bone following total gastrectomy in rats [J].
Morohashi, T ;
Ohta, A ;
Yamada, S .
JAPANESE JOURNAL OF PHARMACOLOGY, 2000, 82 (01) :54-58
[8]  
OHTA A, 1994, INT J VITAM NUTR RES, V64, P316
[9]  
Ohta A, 2002, J NUTR, V132, P2048
[10]  
Ohta A., 1993, Nippon Eiyo Shokuryo Gakkaishi = Journal of the Japanese Society of Nutrition and Food Science, V46, P123