Neurodevelopmental involvement in schizophrenia: the olfactory epithelium as an alternative model for research

被引：33

作者：

Cascella, Nicola G.

Takaki, Manabu

Lin, Sandra

Sawa, Akira

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Otolaryngol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Program Cellular & Mol Med, Baltimore, MD 21287 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 2007年 / 102卷 / 03期

关键词：

neurodevelopment; olfactory epithelium; schizophrenia;

D O I：

10.1111/j.1471-4159.2007.04628.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been suggested that disturbances during neurodevelopment may play a crucial role in the etiology of schizophrenia (SZ). This premise is supported by brain imaging, epidemiological, and pathological studies as well as the discovery of susceptibility genes for SZ that appear to be implicated in development of the central nervous system. Here, we discuss the limitations of the current methods and models for studying the neurodevelopmental implications in SZ. We agree with the proposal that the olfactory epithelium, in which neurodevelopment continues throughout life, might represent an alternative model for understanding the pathophysiology of the disorder.

引用

收藏

页码：587 / 594

页数：8

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