Study of the evolution and degradation products of ciprofloxacin and oxolinic acid in river water samples by HPLC-UV/MS/MS-MS

被引：58

作者：

Turiel, E ^{[1
]}

Bordin, G ^{[1
]}

Rodríguez, AR ^{[1
]}

机构：

[1] Commiss European Communities, Joint Res Ctr, Inst Reference Mat & Measurements, B-2440 Geel, Belgium

来源：

JOURNAL OF ENVIRONMENTAL MONITORING | 2005年 / 7卷 / 03期

关键词：

D O I：

10.1039/b413506g

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The results of a degradation study of the (fluoro) quinolone antibiotics ciprofloxacin and oxolinic acid in river water samples are presented in this paper. The decomposition of these compounds at ambient temperature was monitored during five months by HPLC-UV, and two consecutive degradation processes ( photo- and bio/chemical- degradation) were observed in both cases although with different degradation rates. Ciprofloxacin was completely degraded after 3 months whereas 80% of oxolinic acid remained unaltered after five months of storage. The analysis of the degradation compounds formed was carried out using MS and tandem MS-MS, allowing the identification of four new ciprofloxacin transformation products not previously described in the literature. Possible degradation pathways for this antibiotic in river water are proposed.

引用

页码：189 / 195

页数：7

共 24 条

[1] Photophysics and photochemistry of fluoroquinolones [J].