Inhibition of lipid peroxidation mediated by indolizines

被引：66

作者：

Nasir, AI

Gundersen, LL

Rise, F

Antonsen, O

Kristensen, T

Langhelle, B

Bast, A

Custers, I

Haenen, GRMM

Wikström, H

机构：

[1] Univ Oslo, Dept Chem, N-0315 Oslo, Norway

[2] Hedemark Coll, Dept Nat Sci, N-2322 Ridabu, Norway

[3] Free Univ Amsterdam, Leiden Amsterdam Ctr Drug Res, NL-1081 HV Amsterdam, Netherlands

[4] Univ Groningen, Ctr Pharm, Dept Med Chem, NL-9713 AV Groningen, Netherlands

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(98)00313-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Esters, ethers, carbonates and carbamates of 1-indolizinols and azaindolizinols exhibit a profound inhibition of lipid peroxidation in vitro. The antioxidants were prepared by cyclization of pyridines and diazines with diphenylcyclopropenone followed by introduction of the O-substituent. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1829 / 1832

页数：4

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