Exogenous antigens and the stimulation of MHC class I restricted cell-mediated cytotoxicity: possible strategies for fish vaccines

被引：30

作者：

Dijkstra, JM

Fischer, U

Sawamoto, Y

Ototake, M ^{[1
]}

Nakanishi, T

机构：

[1] Natl Res Inst Aquaculture, Immunol Sect, Tamaki, Mie 5190423, Japan

[2] Friedrich Loeffler Inst, Inst Diagnost Virol, D-17498 Insel Riems, Germany

[3] Nagano Prefectural Expt Stn Fisheries, Nagano 3997102, Japan

来源：

FISH & SHELLFISH IMMUNOLOGY | 2001年 / 11卷 / 06期

基金：

日本科学技术振兴机构;

关键词：

MHC class I; cell-mediated cytotoxicity; exogenous antigen; adjuvant; teleost;

D O I：

10.1006/fsim.2001.0351

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

An MHC class I restricted cytotoxic T lymphocyte (CTL) activity assay has recently been established for rainbow trout. MHC class I restricted cytotoxicity probably plays a critical role in immunity to most viral diseases in mammals and may play a similar role in fish. Therefore, it is very important to investigate what types of vaccines can stimulate this immune response. Although logical candidates for vaccine components that can stimulate an MHC class I restricted response are live attenuated viruses and DNA vaccines, these materials are generally not allowed in fish for commercial vaccine use due to potential safety issues. In mammals, however. a number of interesting vaccination strategies based on exogenous antigens that stimulate MHC class I restricted cytotoxicity have been described. Several of these strategies are discussed in this review in the context of fish vaccination. (C) 2001 Academic Press.

引用

页码：437 / 458

页数：22

共 121 条

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