Regulation by Small RNAs in Bacteria: Expanding Frontiers

被引:887
作者
Storz, Gisela [1 ]
Vogel, Joerg [2 ]
Wassarman, Karen M. [3 ]
机构
[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Cell Biol & Metab Program, 18 Lib Dr, Bethesda, MD 20892 USA
[2] Univ Wurzburg, Inst Mol Infect Biol, D-97080 Wurzburg, Germany
[3] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA
关键词
STAPHYLOCOCCUS-AUREUS REVEALS; TARGET MESSENGER-RNAS; ESCHERICHIA-COLI; SOLUBLE-RNA; 6S RNA; ANTISENSE RNAS; GENE-EXPRESSION; TRANSLATIONAL INITIATION; LISTERIA-MONOCYTOGENES; CATABOLITE REPRESSION;
D O I
10.1016/j.molcel.2011.08.022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Research on the discovery and characterization of small, regulatory RNAs in bacteria has exploded in recent years. These sRNAs act by base pairing with target mRNAs with which they share limited or extended complementarity, or by modulating protein activity, in some cases by mimicking other nucleic acids. Mechanistic insights into how sRNAs bind mRNAs and proteins, how they compete with each other, and how they interface with ribonucleases are active areas of discovery. Current work also has begun to illuminate how sRNAs modulate expression of distinct regulons and key transcription factors, thus integrating sRNA activity into extensive regulatory networks. In addition, the application of RNA deep sequencing has led to reports of hundreds of additional sRNA candidates in a wide swath of bacterial species. Most importantly, recent studies have served to clarify the abundance of remaining questions about how, when, and why sRNA-mediated regulation is of such importance to bacterial lifestyles.
引用
收藏
页码:880 / 891
页数:12
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