Research on the discovery and characterization of small, regulatory RNAs in bacteria has exploded in recent years. These sRNAs act by base pairing with target mRNAs with which they share limited or extended complementarity, or by modulating protein activity, in some cases by mimicking other nucleic acids. Mechanistic insights into how sRNAs bind mRNAs and proteins, how they compete with each other, and how they interface with ribonucleases are active areas of discovery. Current work also has begun to illuminate how sRNAs modulate expression of distinct regulons and key transcription factors, thus integrating sRNA activity into extensive regulatory networks. In addition, the application of RNA deep sequencing has led to reports of hundreds of additional sRNA candidates in a wide swath of bacterial species. Most importantly, recent studies have served to clarify the abundance of remaining questions about how, when, and why sRNA-mediated regulation is of such importance to bacterial lifestyles.
机构:
Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USAMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Barrick, Jeffrey E.
;
Yu, Dong Su
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Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South Korea
Chungnam Natl Univ, Dept Comp Sci & Engn, Taejon 305764, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Yu, Dong Su
;
Yoon, Sung Ho
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Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Yoon, Sung Ho
;
Jeong, Haeyoung
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Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Jeong, Haeyoung
;
Oh, Tae Kwang
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Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South Korea
21C Frontier Microbial Genom & Applicat Ctr, Taejon 305806, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Oh, Tae Kwang
;
Schneider, Dominique
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机构:
Univ Grenoble 1, CNRS, UMR 5163, Inst Jean Roget,Lab Adaptat & Pathogenie Microorg, F-38042 Grenoble 9, FranceMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Schneider, Dominique
;
Lenski, Richard E.
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Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USAMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Lenski, Richard E.
;
Kim, Jihyun F.
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Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South Korea
Univ Sci & Technol, Sch Sci, Funct Genom Program, Taejon 305333, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
机构:
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
机构:
Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USAMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Barrick, Jeffrey E.
;
Yu, Dong Su
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机构:
Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South Korea
Chungnam Natl Univ, Dept Comp Sci & Engn, Taejon 305764, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Yu, Dong Su
;
Yoon, Sung Ho
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机构:
Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Yoon, Sung Ho
;
Jeong, Haeyoung
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机构:
Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Jeong, Haeyoung
;
Oh, Tae Kwang
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机构:
Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South Korea
21C Frontier Microbial Genom & Applicat Ctr, Taejon 305806, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Oh, Tae Kwang
;
Schneider, Dominique
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机构:
Univ Grenoble 1, CNRS, UMR 5163, Inst Jean Roget,Lab Adaptat & Pathogenie Microorg, F-38042 Grenoble 9, FranceMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Schneider, Dominique
;
Lenski, Richard E.
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h-index: 0
机构:
Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USAMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
Lenski, Richard E.
;
Kim, Jihyun F.
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h-index: 0
机构:
Korea Res Inst Biosci & Biotechnol, Ind Biotechnol & Bioenergy Res Ctr, Taejon 305806, South Korea
Univ Sci & Technol, Sch Sci, Funct Genom Program, Taejon 305333, South KoreaMichigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
机构:
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USAMIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA