Human plasma PeptideAtlas

被引：111

作者：

Deutsch, EW

Eng, JK

Zhang, H

King, NL

Nesvizhskii, AI

Lin, BY

Lee, HK

Yi, EC

Ossola, R

Aebersold, R

机构：

[1] Inst Syst Biol, Seattle, WA 98103 USA

[2] ETH, Inst Mol Syst Biol, Zurich, Switzerland

[3] Univ Zurich, Fac Nat Sci, Zurich, Switzerland

来源：

PROTEOMICS | 2005年 / 5卷 / 13期

关键词：

databases; human; Human Proteome Organisation; plasma proteome; tandem mass spectrometry;

D O I：

10.1002/pmic.200500160

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Peptide identifications of high probability from 28 LC-MS/MS human serum and plasma Received: March 16,2005 experiments from eight different laboratories, carried out in the context of the HUPO Plasma Accepted: March 31, 2005 Proteome Project, were combined and mapped to the EnsEMBL human genome. The 6929 distinct observed peptides were mapped to approximately 960different proteins. The resulting compendium of peptides and their associated samples, proteins, and genes is made publicly available as a reference for future research on human plasma.

引用

收藏

页码：3497 / 3500

页数：4

相关论文

共 15 条

[1] Toward a human blood serum proteome - Analysis by multidimensional separation coupled with mass spectrometry [J].

Adkins, JN ;

Varnum, SM ;

Auberry, KJ ;

Moore, RJ ;

Angell, NH ;

Smith, RD ;

Springer, DL ;

Pounds, JG .

MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (12) :947-955

[2] The human plasma proteome - History, character, and diagnostic prospects [J].

Anderson, NL ;

Anderson, NG .

MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (11) :845-867

[3] The human plasma proteome - A nonredundant list developed by combination of four separate sources [J].

Anderson, NL ;

Polanski, M ;

Pieper, R ;

Gatlin, T ;

Tirumalai, RS ;

Conrads, TP ;

Veenstra, TD ;

Adkins, JN ;

Pounds, JG ;

Fagan, R ;

Lobley, A .

MOLECULAR & CELLULAR PROTEOMICS, 2004, 3 (04) :311-326

[4]

Chan K. C., 2004, CLIN PROTEOM, V1, P101, DOI DOI 10.1385/CP:1:2:101

[5]

Desiere F, 2005, GENOME BIOL, V6

[6] AN APPROACH TO CORRELATE TANDEM MASS-SPECTRAL DATA OF PEPTIDES WITH AMINO-ACID-SEQUENCES IN A PROTEIN DATABASE [J].

ENG, JK ;

MCCORMACK, AL ;

YATES, JR .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 1994, 5 (11) :976-989

[7] Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search [J].

Keller, A ;

Nesvizhskii, AI ;

Kolker, E ;

Aebersold, R .

ANALYTICAL CHEMISTRY, 2002, 74 (20) :5383-5392

[8] The International Protein Index: An integrated database for proteomics experiments [J].

Kersey, PJ ;

Duarte, J ;

Williams, A ;

Karavidopoulou, Y ;

Birney, E ;

Apweiler, R .

PROTEOMICS, 2004, 4 (07) :1985-1988

[9] Advancement of biomarker discovery and validation through the HUPO plasma proteome project [J].

Omenn, GS .

DISEASE MARKERS, 2004, 20 (03) :131-134

[10] The Human Proteome Organization Plasma Proteome Project pilot phase: Reference specimens, technology platform comparisons, and standardized data submissions and analyses [J].

Omenn, GS .

PROTEOMICS, 2004, 4 (05) :1235-1240