We investigate model independent upper bounds on total proton lifetime in the context of grand unified theories with the Standard Model matter content. We find them to be tau(p) <= 1.5(-0.3)(+0.5) x 10(39) alpha(2)(GUT)/ (M-X/10(16) GeV)(4) (0.003 GeV3 /alpha)(2) years and tau(p) <= 7.1(-0.0)(+0.0) x 10(36) alpha(2)(GUT)/ (M-X/10(16) GeV)(4) (.003 GeV3/alpha)(2) years in the Majorana and Dirac neutrino case, respectively. These bounds, in conjunction with experimental limits, put lower limit on the mass M-X of gauge bosons responsible for the proton and bound-neutron decay processes. For central values of relevant input parameters we obtain M-X >= 4.3 x 10(14) root alpha GUT GeV. Our result implies that a large class of non-supersymmetric grand unified models, with typical values alpha GUT similar to 1/39, still satisfies experimental constraints on proton lifetime. Our result is independent on any CP violating phase and the only significant source of uncertainty is associated with imprecise knowledge of alpha-the nucleon decay matrix element. (c) 2005 Published by Elsevier B.V.