Statins and cancer prevention

被引：671

作者：

Demierre, MF

Higgins, PDR

Gruber, SB

Hawk, E

Lippman, SM ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Clin Canc Prevent, Houston, TX 77230 USA

[2] Boston Univ, Sch Med, Dept Dermatol, Boston, MA 02118 USA

[3] Univ Michigan, Med Ctr, Dept Internal Med, Div Med & Mol Genet, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Med Ctr, Dept Epidemiol & Human Genet, Ann Arbor, MI 48109 USA

[5] NCI, Off Ctr Training & Resources, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1751

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have led to the intensive study of statins in cancer prevention, including recent, large population-based studies showing statin-associated reductions in overall, colorectal and prostate cancer. Understanding the complex cellular effects (for example, on angiogenesis and inflammation) and the underlying molecular mechanisms of statins (for example, 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase-dependent processes that involve geranylgeranylation of Rho proteins, and HMG-CoA-independent processes that involve lymphocyte-function-associated antigen 1) will advance the development of molecularly targeted agents for preventing cancer. This understanding might also help the development of drugs for other ageing-related diseases with interrelated molecular pathways.

引用

收藏

页码：930 / 942

页数：13

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