Antineoplastic activity of sterically stabilized alkylphosphocholine liposomes in human breast carcinomas

被引：24

作者：

Arndt, D ^{[1
]}

Zeisig, R ^{[1
]}

Eue, I ^{[1
]}

Sternberg, B ^{[1
]}

Fichtner, I ^{[1
]}

机构：

[1] UNIV JENA,INST ULTRASTRUCT RES,D-6900 JENA,GERMANY

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1997年 / 43卷 / 03期

关键词：

alkylphosphocholine; hexadecylphosphocholine; human breast carcinoma; sterically stabilized liposomes;

D O I：

10.1023/A:1005798715192

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

New sterically stabilized liposomes derived from the antitumor agent hexadecylphosphocholine with reduced uptake by the mononuclear phagocyte system and improved antitumor activities were developed and tested. The bilayer of such sterically stabilized liposomes consists of hexadecylphosphocholine, cholesterol and polyethylene glycol-linked phosphoethanolamine. The measurement of carbon clearance in mice shows that these stabilized liposomes, in contrast to conventional alkylphosphocholine liposomes, are not largely engulfed by the mononuclear phagocyte system. Their therapeutic activity on experimental human breast carcinomas MaTu, MT-1 and MT-3 was tested in nude mice. Especially in the MaTu models the sterically stabilized hexadecylphosphocholine liposomes resulted in significantly reduced tumor growth in comparison to conventional hexadecylphosphocholine liposomes or free hexadecylphosphocholine. The enhanced therapeutic efficacy of sterically stabilized hexadecylphosphocholine liposomes is probably related to the extended circulation time of the formulation and its accumulation in tumors.

引用

页码：237 / 246

页数：10

共 39 条

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