High rate of aminoglycoside resistance among staphylococci causing prosthetic joint infection

被引:66
作者
Anguita-Alonso, P
Hanssen, AD
Osmon, DR
Trampuz, A
Steckelberg, JM
Patel, R
机构
[1] Mayo Clin, Div Infect Dis, Coll Med, Dept Internal Med, Rochester, MN 55905 USA
[2] Mayo Clin, Coll Med, Dept Orthoped Surg, Rochester, MN 55905 USA
[3] Mayo Clin, Coll Med, Div Clin Microbiol, Dept Lab Med & Pathol, Rochester, MN 55905 USA
关键词
D O I
10.1097/01.blo.0000182394.39601.9d
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Gentamicin and tobramycin are two aminoglycosides commonly impregnated into polymethylmethacrylate for treatment and prevention of prosthetic joint infection. Susceptibilities of staphylococci to aminoglycosides are not reported routinely in the United States. The gentamicin and tobramycin minimum inhibitory value of 93 staphylococci from patients with PJI were determined. Forty-one and 66% of the isolates were resistant to gentamicin and tobramycin, respectively. Methicillin-resistant Staphylococcus aureus isolates were more likely to be resistant to gentamicin or tobramycin than were their methicillin susceptible counterparts. The findings suggest that consideration should be given to the further study of agents other than aminoglycosides for incorporation into polymethylmethacrylate for the treatment and prevention of prosthetic joint infection.
引用
收藏
页码:43 / 47
页数:5
相关论文
共 23 条
[1]   Risk factors for prosthetic joint infection: Case-control study [J].
Berbari, EF ;
Hanssen, AD ;
Duffy, MC ;
Steckelberg, JM ;
Ilstrup, DM ;
Harmsen, WS ;
Osmon, DR .
CLINICAL INFECTIOUS DISEASES, 1998, 27 (05) :1247-1254
[2]   Antibiotic resistance - to treat ... [J].
Blower, S ;
Koelle, K ;
Lietman, T .
NATURE MEDICINE, 1999, 5 (04) :358-358
[3]   Methicillin resistance in staphylococci: Molecular and biochemical basis and clinical implications [J].
Chambers, HF .
CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (04) :781-+
[4]   Treatment of infection with debridement and retention of the components following hip arthroplasty [J].
Crockarell, JR ;
Hanssen, AD ;
Osmon, DR ;
Morrey, BF .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1998, 80A (09) :1306-1313
[5]   Survey of infections due to Staphylococcus species:: Frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific region for the SENTRY Antimicrobial Surveillance Program, 1997-1999 [J].
Diekema, DJ ;
Pfaller, MA ;
Schmitz, FJ ;
Smayevsky, J ;
Bell, J ;
Jones, RN ;
Beach, M .
CLINICAL INFECTIOUS DISEASES, 2001, 32 :S114-S132
[6]  
Hanssen A D, 1999, Instr Course Lect, V48, P111
[7]   USE OF ANTIBIOTIC-IMPREGNATED CEMENT DURING HIP AND KNEE ARTHROPLASTY IN THE UNITED-STATES [J].
HECK, D ;
ROSENBERG, A ;
SCHINKASCANI, M ;
GARBUS, S ;
KIEWITT, T .
JOURNAL OF ARTHROPLASTY, 1995, 10 (04) :470-475
[8]   LOCAL ANTIBACTERIAL THERAPY FOR THE MANAGEMENT OF ORTHOPEDIC INFECTIONS - PHARMACOKINETIC CONSIDERATIONS [J].
HENRY, SL ;
GALLOWAY, KP .
CLINICAL PHARMACOKINETICS, 1995, 29 (01) :36-45
[9]   DEEP INFECTION OF CEMENTED TOTAL HIP ARTHROPLASTIES CAUSED BY COAGULASE-NEGATIVE STAPHYLOCOCCI [J].
HOPE, PG ;
KRISTINSSON, KG ;
NORMAN, P ;
ELSON, RA .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 1989, 71 (05) :851-855
[10]  
Jackson WO, 2000, CLIN ORTHOP RELAT R, P101