Nanoparticle-Based Dressing: The Future of Wound Treatment?

被引：236

作者：

Berthet, Morgane ^{[1
]}

Gauthier, Yves ^{[2
]}

Lacroix, Celine ^{[1
]}

Verrier, Bernard ^{[1
]}

Monge, Claire ^{[1
]}

机构：

[1] Univ Lyon 1, Lab Biol Tissulaire & Ingn Therapeut LBTI, UMR 5305, CNRS,IBCP, Lyon, France

[2] IRBA, Dept Malad Infect, Bretigny Sur Orge, France

来源：

TRENDS IN BIOTECHNOLOGY | 2017年 / 35卷 / 08期

关键词：

IN-VITRO; GROWTH-FACTOR; EPIGALLOCATECHIN GALLATE; SILVER NANOPARTICLES; TOPICAL TREATMENT; EX-VIVO; DELIVERY; SKIN; CHITOSAN; PLGA;

D O I：

10.1016/j.tibtech.2017.05.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Reconstructing functional skin after a wound remains a challenge due to the complexity of healing. In this regard, biocompatible nanoparticles (NPs) carrying and releasing bioactive drugs in a controlled and sustained manner may significantly improve the efficacy of wound therapies compared with current treatments. Topical administration of drug-loaded NPs allows optimal delivery to the dermis and improves product efficacy. Furthermore, associating NPs with scaffolds represents a new concept of 'dressing'. Experimental in vivo, ex vivo, and in vitro models have been developed in preclinical assays to evaluate the beneficial effects of nanoparticulate dressings. Drug-loaded NPs are promising tools for innovative wound healing treatment, especially with regard to their multifunctional properties.

引用

页码：770 / 784

页数：15

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