The identification of novel therapeutic targets for the treatment of malignant brain tumors

被引：104

作者：

Kroes, RA

Jastrow, A

McLone, MG

Yamamoto, H

Colley, P

Kersey, DS

Yong, VW

Mkrdichian, E

Cerullo, L

Leestma, J

Moskal, JR

机构：

[1] Chicago Inst Neurosurg & Neurores, Chicago, IL 60614 USA

[2] Univ Calgary, Dept Oncol, Calgary, AB, Canada

[3] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

来源：

CANCER LETTERS | 2000年 / 156卷 / 02期

关键词：

differential display; glioma; expression screen;

D O I：

10.1016/S0304-3835(00)00462-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A two-step strategy was developed consisting of differential display reverse transcriptase polymerase chain reaction (DDRT-PCR) with cultured normal human fetal astrocytes and U-373MG glioma cells followed by reverse Northern analysis of normal brain and primary tumor tissues. hu-dek, alpha -NAC, ribosomal proteins L7a and L35a, and five novel genes were identified. Since none of these genes has been previously shown to be associated with malignant brain tumor formation, this approach may be useful to identify novel targets for the diagnosis and treatment of brain tumors. (C) 2000 Published by Elsevier Science Ireland Ltd, All rights reserved.

引用

页码：191 / 198

页数：8

共 34 条

[1] Recent advances in the biology of central nervous system tumors [J].