Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts

被引：78

作者：

Di Mambro, VM ^{[1
]}

Fonseca, MJV ^{[1
]}

机构：

[1] USP, Fac Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, BR-14040903 Ribeirao Preto, SP, Brazil

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2005年 / 37卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

topical formulation; antioxidant flavonoids; viscosity; plant extract;

D O I：

10.1016/j.jpba.2004.10.030

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In the present investigation the changes on physical stability (pH, viscosity, flow index and tixotropy) of topical formulations were evaluated following inclusion of different plant extracts containing flavonoids. Also, the antioxidant effect of these plant extracts alone and after addition, 41 in the formulation was evaluated using chemiluminescence and the stable free radical 1, 1 -diphenyl-2-picrylhydrazyl (DPPH.) assays, as well as the inhibition of lipid peroxidation. Formulation added with DL-alpha-tocopherol was used to compare the physical stability and antioxidant activity. Formulations with plant extracts showed pseudoplastic behavior with decreasing on viscosity and tixotropy. The Glycyrrhiza glabra (GG) and Ginkgo biloba (GB) extracts alone and the formulations containing these extracts showed great antioxidant and free radical scavenging activities while the other extracts studied (mixture of Glycyrrhiza glabra, Symphytum officinale L and Arctium majus root, Nelumbium speciosum and soybean) showed lower activity. The results suggest that GG and GB extracts may be used in topical formulations in order to protect skin against damage caused by free radical and reactive oxygen species. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：287 / 295

页数：9

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