Chatting histone modifications in mammals

被引：89

作者：

Izzo, Annalisa ^{[1
]}

Schneider, Robert ^{[1
]}

机构：

[1] MPI Immunobiol, D-79108 Freiburg, Germany

来源：

BRIEFINGS IN FUNCTIONAL GENOMICS | 2010年 / 9卷 / 5-6期

基金：

欧洲研究理事会;

关键词：

histone modifications; histone methylation; cross-talk; epigenetic; chromatin; H3; METHYLATION; ARGININE METHYLTRANSFERASE; LYSINE METHYLATION; POSTTRANSLATIONAL MODIFICATIONS; INTERGENIC TRANSCRIPTION; CHROMATIN MODIFICATIONS; H2B MONOUBIQUITINATION; RECEPTOR FUNCTION; GLOBULAR DOMAIN; CROSS-TALK;

D O I：

10.1093/bfgp/elq024

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Eukaryotic chromatin can be highly dynamic and can continuously exchange between an open transcriptionally active conformation and a compacted silenced one. Post-translational modifications of histones have a pivotal role in regulating chromatin states, thus influencing all chromatin dependent processes. Methylation is currently one of the best characterized histone modification and occurs on arginine and lysine residues. Histone methylation can regulate other modifications (e. g. acetylation, phosphorylation and ubiquitination) in order to define a precise functional chromatin environment. In this review we focus on histone methylation and demethylation, as well as on the enzymes responsible for setting these marks. In particular we are describing novel concepts on the interdependence of histone modifications marks and discussing the molecular mechanisms governing this cross-talks.

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页码：429 / 443

页数：15

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