Multiple resistance mechanisms to azole antifungals in yeast clinical isolates

被引：75

作者：

Sanglard, D ^{[1
]}

Ischer, F ^{[1
]}

Calabrese, D ^{[1
]}

de Micheli, M ^{[1
]}

Bille, J ^{[1
]}

机构：

[1] CHU Vaudois, Inst Microbiol, CH-1011 Lausanne, Switzerland

来源：

DRUG RESISTANCE UPDATES | 1998年 / 1卷 / 04期

关键词：

D O I：

10.1016/S1368-7646(98)80006-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The use of antifungal agents, especially the azole class, has increased in parallel with a higher incidence of fungal infections, particularly in immunocompromised patients. This situation has favored the appearance of Candida species, prominent among them C, albicans and C, globrata, with acquit-ed resistance to these agents. This review focuses on the latest developments in investigations of molecular mechanisms contributing to azole resistance. Multiple resistance mechanisms have been described that can coexist in resistant clinical isolates. Understanding resistance mechanisms is of value not only for the design of new antifungal agents but also the development of strategies of overcome or delay the emergence of resistance.

引用

页码：255 / 265

页数：11

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