Crystal structure of a yeast TFIIA/TBP/DNA complex

被引：257

作者：

Tan, S ^{[1
]}

Hunziker, Y ^{[1
]}

Sargent, DF ^{[1
]}

Richmond, TJ ^{[1
]}

机构：

[1] ETH HONGGERBERG,INST MOLEK BIOL & BIOPHYS,CH-8093 ZURICH,SWITZERLAND

来源：

NATURE | 1996年 / 381卷 / 6578期

关键词：

D O I：

10.1038/381127a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 Angstrom resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATE box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

引用

页码：127 / 134

页数：8

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