Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud

被引：357

作者：

Kengaku, M

Capdevila, J

Rodriguez-Esteban, C

De La Peña, J

Johnson, RL

Belmonte, JCI

Tabin, CJ

机构：

[1] Salk Inst Biol Studies, La Jolla, CA 92037 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[3] Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

SCIENCE | 1998年 / 280卷 / 5367期

关键词：

D O I：

10.1126/science.280.5367.1274

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The apical ectodermal ridge (AER) is an essential structure for vertebrate limb development. Wnt3a is expressed during the induction of the chick AER, and misexpression of Wnt3a induces ectopic expression of AER-specific genes in the limb ectoderm. The genes beta-catenin and Lef1 can mimic the effect of Wnt3a, and blocking the intrinsic Lef1 activity disrupts AER formation. Hence, Wnt3a functions in AER formation through the beta-catenin/LEF1 pathway. In contrast, neither beta-catenin nor Lef1 affects the Wnt7a-regulated dorsoventral polarity of the limb. Thus, two related Wnt genes elicit distinct responses in the same tissues by using different intracellular pathways.

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页码：1274 / 1277

页数：4

相关论文

共 46 条

[1] Functional interaction of beta-catenin with the transcription factor LEF-1 [J].

Behrens, J ;

vonKries, JP ;

Kuhl, M ;

Bruhn, L ;

Wedlich, D ;

Grosschedl, R ;

Birchmeier, W .

NATURE, 1996, 382 (6592) :638-642

[2] pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila [J].

Brunner, E ;

Peter, O ;

Schweizer, L ;

Basler, K .

NATURE, 1997, 385 (6619) :829-833

[3] Roles for FGF8 in the induction, initiation, and maintenance of chick limb development [J].

Crossley, PH ;

Minowada, G ;

MacArthur, CA ;

Martin, GR .

CELL, 1996, 84 (01) :127-136

[4] WNT-5A AND WNT-7A ARE EXPRESSED IN THE DEVELOPING CHICK LIMB BUD IN A MANNER SUGGESTING ROLES IN PATTERN-FORMATION ALONG THE PROXIMODISTAL AND DORSOVENTRAL AXES [J].

DEALY, CN ;

ROTH, A ;

FERRARI, D ;

BROWN, AMC ;

KOSHER, RA .

MECHANISMS OF DEVELOPMENT, 1993, 43 (2-3) :175-186

[5]

DU SJ, 1995, MOL CELL BIOL, V15, P2625

[6] EMBRYONIC AXIS INDUCTION BY THE ARMADILLO REPEAT DOMAIN OF BETA-CATENIN - EVIDENCE FOR INTRACELLULAR SIGNALING [J].

FUNAYAMA, N ;

FAGOTTO, F ;

MCCREA, P ;

GUMBINER, BM .

JOURNAL OF CELL BIOLOGY, 1995, 128 (05) :959-968

[7] A COMMON ANCESTOR OF THE MAMMALIAN TRANSCRIPTION FACTORS TCF-1 AND TCF-1-ALPHA/LEF-1 EXPRESSED IN CHICKEN T-CELLS [J].

GASTROP, J ;

HOEVENAGEL, R ;

YOUNG, JR ;

CLEVERS, HC .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (05) :1327-1330

[8] EXPRESSION OF MULTIPLE NOVEL WNT-1/INT-1-RELATED GENES DURING FETAL AND ADULT-MOUSE DEVELOPMENT [J].

GAVIN, BJ ;

MCMAHON, JA ;

MCMAHON, AP .

GENES & DEVELOPMENT, 1990, 4 (12B) :2319-2332

[9] Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development [J].

Greco, TL ;

Takada, S ;

Newhouse, MM ;

McMahon, TA ;

McMahon, AP ;

Camper, SA .

GENES & DEVELOPMENT, 1996, 10 (03) :313-324

[10] WNT EXPRESSION PATTERNS IN CHICK-EMBRYO NERVOUS-SYSTEM [J].

HOLLYDAY, M ;

MCMAHON, JA ;

MCMAHON, AP .

MECHANISMS OF DEVELOPMENT, 1995, 52 (01) :9-25

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