Ras - a versatile cellular switch

被引:88
作者
Rommel, C [1 ]
Hafen, E
机构
[1] Regeneron Pharmaceut Inc, Tarrytown, NY 10591 USA
[2] Univ Zurich, Inst Zool, CH-8057 Zurich, Switzerland
关键词
D O I
10.1016/S0959-437X(98)80111-1
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
With the number of known roles played by Ras proteins increasing rapidly, finding answers to how the diverse cellular responses are triggered is becoming increasingly pertinent. Although our understanding of the control of specificity of signal transduction is still small, the combination of biochemical, structural and genetic analyses is starting to reveal how the cell-specific responses to Ras activation are controlled.
引用
收藏
页码:412 / 418
页数:7
相关论文
共 71 条
[1]   14-3-3 and its possible role in co-ordinating multiple signalling pathways [J].
Aitken, A .
TRENDS IN CELL BIOLOGY, 1996, 6 (09) :341-347
[2]   REQUIREMENT OF THE DROSOPHILA RAF HOMOLOG FOR TORSO FUNCTION [J].
AMBROSIO, L ;
MAHOWALD, AP ;
PERRIMON, N .
NATURE, 1989, 342 (6247) :288-291
[3]   The activity of D-raf in Torso signal transduction is altered by serine substitution, N-terminal deletion, and membrane targeting [J].
Baek, KH ;
Fabian, JR ;
Sprenger, F ;
Morrison, DK ;
Ambrosio, L .
DEVELOPMENTAL BIOLOGY, 1996, 175 (02) :191-204
[4]   LIGAND-INDEPENDENT ACTIVATION OF THE SEVENLESS RECEPTOR TYROSINE KINASE CHANGES THE FATE OF CELLS IN THE DEVELOPING DROSOPHILA EYE [J].
BASLER, K ;
CHRISTEN, B ;
HAFEN, E .
CELL, 1991, 64 (06) :1069-1081
[5]   PROTEINS REGULATING RAS AND ITS RELATIVES [J].
BOGUSKI, MS ;
MCCORMICK, F .
NATURE, 1993, 366 (6456) :643-654
[6]   THE GTPASE SUPERFAMILY - A CONSERVED SWITCH FOR DIVERSE CELL FUNCTIONS [J].
BOURNE, HR ;
SANDERS, DA ;
MCCORMICK, F .
NATURE, 1990, 348 (6297) :125-132
[7]   BCR AND RAF FORM A COMPLEX IN-VIVO VIA 14-3-3-PROTEINS [J].
BRASELMANN, S ;
MCCORMICK, F .
EMBO JOURNAL, 1995, 14 (19) :4839-4848
[8]  
CHANG H, 1997, GENE DEV, V11, P1113
[9]   14-3-3 zeta negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain [J].
Clark, GJ ;
Drugan, JK ;
Rossmann, KL ;
Carpenter, JW ;
RogersGraham, K ;
Fu, H ;
Der, CJ ;
Campbell, SL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (34) :20990-20993
[10]   14-3-3-PROTEINS ASSOCIATE WITH CDC25-PHOSPHATASES [J].
CONKLIN, DS ;
GALAKTIONOV, K ;
BEACH, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7892-7896