Antigen processing by the proteasome

被引：495

作者：

Kloetzel, PM ^{[1
]}

机构：

[1] Humboldt Univ, Charite, Fac Med, Inst Biochem, D-10117 Berlin, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 03期

关键词：

D O I：

10.1038/35056572

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes - the waste-disposal units of the cell - typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?.

引用

页码：179 / 187

页数：9

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