Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

被引：118

作者：

Araujo, Robyn P. ^{[1
]}

Liotta, Lance A. ^{[1
]}

Petricoin, Emanuel F. ^{[1
]}

机构：

[1] George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA 20109 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2007年 / 6卷 / 11期

关键词：

D O I：

10.1038/nrd2381

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Realizing the promise of molecularly targeted inhibitors for cancer therapy will require a new level of knowledge about how a drug target is wired into the control circuitry of a complex cellular network. Here we review general homeostatic principles of cellular networks that enable the cell to be resilient in the face of molecular perturbations, while at the same time being sensitive to subtle input signals. Insights into such mechanisms may facilitate the development of combination therapies that take advantage of the cellular control circuitry, with the aim of achieving higher efficacy at a lower drug dosage and with a reduced probability of drug-resistance development.

引用

页码：871 / 880

页数：10

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