Vitamin D receptor genotypes are related to bone size and bone density in men

Three restriction fragment length polymorphisms in the vitamin D receptor gene have been associated with a low bone density in twin and female population studies, but no studies have been conducted exclusively in men. We studied 146 normal men aged 20-83 years. Bone density was measured in the spine, hip, whole body and forearm, and the Bsm polymorphism for the vitamin D receptor was detected by the polymerase chain reaction. Men with genotype BE tended to have a lower bone density at all but one site than the other genotypes. In the men less than or equal to 50 years of age bone density in the forearm was 7% lower in the BE than the Bb and bb groups (P = 0.030) but bone mineral content did not differ between the groups. Bone area was greater in the BE genotype at all sites. This was statistically significant in the forearm (P = 0.026). We conclude that BE genotype is associated with lower bone density in men, which may be due to larger bone size rather than reduced bone mass.