Novel selective inhibitors for human topoisomerase I, BM2419-1 and -2 derived from saintopin

被引：8

作者：

Ishiyama, D ^{[1
]}

Futamata, K ^{[1
]}

Futamata, M ^{[1
]}

Kasuya, O ^{[1
]}

Kamo, S ^{[1
]}

Yamashita, F ^{[1
]}

Kanazawa, S ^{[1
]}

机构：

[1] Kaken Pharmaceut Co LTD, Drug Discovery Res Labs, Fujieda, Shizuoka 4268646, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 12期

关键词：

D O I：

10.7164/antibiotics.51.1069

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively.

引用

页码：1069 / 1074

页数：6

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