Empagliflozin's Fuel Hypothesis: Not so Soon

被引：141

作者：

Lopaschuk, Gary D. ^{[1
]}

Verma, Subodh ^{[2
]}

机构：

[1] Univ Alberta, Cardiovasc Translat Sci Inst, Edmonton, AB T6G 2S2, Canada

[2] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Div Cardiac Surg, Toronto, ON M5S, Canada

来源：

CELL METABOLISM | 2016年 / 24卷 / 02期

关键词：

OXIDATIVE STRESS; OUTCOMES;

D O I：

10.1016/j.cmet.2016.07.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The EMPA-REG OUTCOME trial (Zinman et al., 2015) established cardioprotective effects of empagliflozin in high-risk diabetic patients, but the underlying mechanisms remain elusive. A recent hypothesis proposed that increased ketone oxidation contributed to the effect, but several caveats indicate that the role of myocardial ketone oxidation is far from clear.

引用

收藏

页码：200 / 202

页数：4

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