The interdependence of lung antioxidants and antiprotease defense in ARDS

被引：34

作者：

Gadek, JE ^{[1
]}

Pacht, ER ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT INTERNAL MED,COLUMBUS,OH 43210

来源：

CHEST | 1996年 / 110卷 / 06期

关键词：

adult respiratory distress syndrome; antioxidant; antiprotease; alpha(1)-antitrypsin; neutrophil elastase; oxidant; protease; surfactant;

D O I：

10.1378/chest.110.6_Supplement.273S

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

As in hereditary alpha(1)-antitrypsin deficiency, protease-antiprotease and oxidant-antioxidant balances play a significant role in the pathogenesis of ARDS. However, the disease processes and possibilities for therapeutic intervention differ markedly.

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收藏

页码：S273 / S277

页数：5

相关论文

共 13 条

[1] OXIDIZED GLUTATHIONE IS INCREASED IN THE ALVEOLAR FLUID OF PATIENTS WITH THE ADULT-RESPIRATORY-DISTRESS-SYNDROME [J].

BUNNELL, E ;

PACHT, ER .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (05) :1174-1178

[2]

GREGORY TJ, 1994, AM J RESP CRIT CARE, V149, pA567

[3] PROTEIN PERMEABILITY IN THE ADULT RESPIRATORY-DISTRESS SYNDROME - LOSS OF SIZE SELECTIVITY OF THE ALVEOLAR EPITHELIUM [J].

HOLTER, JF ;

WEILAND, JE ;

PACHT, ER ;

GADEK, JE ;

DAVIS, WB .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 78 (06) :1513-1522

[4] MEDICAL PROGRESS - THE ACUTE RESPIRATORY-DISTRESS SYNDROME [J].

KOLLEF, MH ;

SCHUSTER, DP .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (01) :27-37

[5] ELASTOLYTIC ACTIVITY IN PULMONARY LAVAGE FLUID FROM PATIENTS WITH ADULT RESPIRATORY-DISTRESS SYNDROME [J].

LEE, CT ;

FEIN, AM ;

LIPPMANN, M ;

HOLTZMAN, H ;

KIMBEL, P ;

WEINBAUM, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 304 (04) :192-196

[6] ANTIOXIDANT ACTIVITY OF BRONCHOALVEOLAR LAVAGE FLUID IN THE ADULT RESPIRATORY-DISTRESS SYNDROME [J].

LYKENS, MG ;

DAVIS, WB ;

PACHT, ER .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (02) :L169-L175

[7]

MAUNDER RJ, 1985, CLIN CHEST MED, V6, P413

[8] IMPROVED SURVIVAL OF PATIENTS WITH ACUTE RESPIRATORY-DISTRESS-SYNDROME (ARDS) - 1983-1993 [J].

MILBERG, JA ;

DAVIS, DR ;

STEINBERG, KP ;

HUDSON, LD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (04) :306-309

[9] CLINICAL PREDICTORS OF THE ADULT RESPIRATORY-DISTRESS SYNDROME [J].

PEPE, PE ;

POTKIN, RT ;

REUS, DH ;

HUDSON, LD ;

CARRICO, CJ .

AMERICAN JOURNAL OF SURGERY, 1982, 144 (01) :124-130

[10] INCREASED INTESTINAL PROTEIN PERMEABILITY IN A MODEL OF LUNG INJURY INDUCED BY PHORBOL-MYRISTATE ACETATE [J].

STJOHN, RC ;

MIZER, LA ;

WEISBRODE, SE ;

DORINSKY, PM .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (05) :1171-1176