Vitamin D and the brain

被引：216

作者：

Harms, Lauren R. ^{[1
]}

Burne, Thomas H. J. ^{[1
]}

Eyles, Darryl W. ^{[1
]}

McGrath, John J. ^{[1
]}

机构：

[1] Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2011年 / 25卷 / 04期

基金：

英国医学研究理事会;

关键词：

Vitamin D; brain development; schizophrenia; neurosteroids; animal models; D DEFICIENCY ALTERS; 1,25-DIHYDROXYVITAMIN-D3 RECEPTOR IMMUNOREACTIVITY; CENTRAL-NERVOUS-SYSTEM; RAT-BRAIN; ADULT-RAT; LATENT INHIBITION; ANIMAL-MODEL; D SUPPLEMENTATION; CARCINOMA-CELLS; D INSUFFICIENCY;

D O I：

10.1016/j.beem.2011.05.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamin D is a member of the superfamily of nuclear steroid transcription regulators and as such, exerts transcriptional control over a large number of genes. Several other steroids, such as thyroid hormones, vitamin A, androgens and the glucocorticoids, are known as 'neurosteroids' and their role in brain development and function is well defined. It has only been in the last decade or so that vitamin D has been thought to function as a neurosteroid. In this review we have collated a diverse array of data describing the presence of vitamin D metabolites and the receptor in the brain, the evidence that vitamin D may be an important modulator of brain development, and the potential role of vitamin D in neurological and neuropsychiatric disorders. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：657 / 669

页数：13

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