Process monitoring of an industrial fed-batch fermentation

被引：131

作者：

Lennox, B

Montague, GA

Hiden, HG

Kornfeld, G

Goulding, PR

机构：

[1] Univ Manchester, Sch Engn, Control Technol Ctr, Manchester M13 9PL, Lancs, England

[2] Newcastle Univ, Dept Chem & Proc Engn, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Biochem Ltd, Kundl, Austria

来源：

BIOTECHNOLOGY AND BIOENGINEERING | 2001年 / 74卷 / 02期

关键词：

fault detection; fault diagnosis; fermentation; multivariate statistical process control; principal component analysis;

D O I：

10.1002/bit.1102

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Market demand places great emphasis in industry on product quality. Consequently, process monitoring and control have become important aspects of systems engineering. In this article we detail the results of a 2-year study focusing on the development of a condition monitoring system for a fed-batch fermentation system operated by Biochemie Gmbh in Austria. We also demonstrate the suitability and limitations of current state of the art technologies in this field and suggest novel modifications and configurations to improve their suitability for application to a fed-batch fermentation system. (C) 2001 John Wiley & Sons, Inc.

引用

页码：125 / 135

页数：11

共 28 条

[1] SOME THEOREMS ON QUADRATIC FORMS APPLIED IN THE STUDY OF ANALYSIS OF VARIANCE PROBLEMS .1. EFFECT OF INEQUALITY OF VARIANCE IN THE ONE-WAY CLASSIFICATION [J].