In vivo models of thrombosis for the antiphospholipid syndrome

被引：45

作者：

Pierangeli, SS ^{[1
]}

Harris, EN ^{[1
]}

机构：

[1] MOREHOUSE SCH MED, DEPT INTERNAL MED, ATLANTA, GA 30310 USA

来源：

LUPUS | 1996年 / 5卷 / 05期

关键词：

antiphospholipid antibodies; antiphospholipid syndrome; murine model of thrombosis;

D O I：

10.1177/096120339600500524

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Utilizing this unique animal model of thrombosis we demonstrated that human (IgG, IgM or IgA) polyclonal and monoclonal antiphospholipid antibodies derived from APS patients have a significant enhancing effect on thrombus formation. This effect is reversed by treatment of the mice with hydroxychloroquine (plaquenil). In addition murine polyclonal and monoclonal anticardiolipin antibodies induced by active immunization with human beta(2)-GP1 or human anticardiolipin antibodies showed to have thrombogenic properties in CD1 mice. Antibodies with antihuman beta(2)-GP1 activity alone did not seem to affect thrombus formation.

引用

页码：451 / 455

页数：5

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