Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system

被引:56
作者
Champtiaux, N [1 ]
Changeux, JP [1 ]
机构
[1] Inst Pasteur, CNR, Mol Neurobiol Lab, Unite Rech Associee 2182 Recepteurs & Cognit, F-75724 Paris 15, France
来源
ACETYLCHOLINE IN THE CEREBRAL CORTEX | 2004年 / 145卷
关键词
addiction; aging; Alzheimer's disease; analgesia; attention; cognition; development; dopaminergic; knockout; knockin; neurodegeneration; nicotinic receptors; reinforcement; schizophrenia;
D O I
10.1016/S0079-6123(03)45016-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The recent use of genetically engineered knockout (Ko) and knockin (Kin) animals for neurotransmitter receptor genes, in particular, nicotinic acetylcholine receptors (nAChRs) in the brain, has provided a powerful alternative to the classical pharmacological approach. These animal models are not only useful in order to reexamine and refine the results derived from pharmacological studies, but they do also provide a unique opportunity to determine the subunit composition of the nicotinic receptors which modulate various brain functions. Ultimately, this knowledge will be valuable in the process of designing new drugs that will mimic the effects of nicotine on several important pathologies or on smoking cessation therapies. In this review, we present recent data obtained from the studies of mutant animals that contributed to our understanding of the role and composition of nAChRs in the central nervous system (CNS). The advantages and pitfalls of Ko animal models will also be discussed.
引用
收藏
页码:235 / 251
页数:17
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