Evolution of platinum resistance in high-grade serous ovarian cancer

被引：210

作者：

Cooke, Susanna L. ^{[1
]}

Brenton, James D. ^{[1
]}

机构：

[1] Canc Res UK Cambridge Res Inst, Li Ka Shing Ctr, Cambridge CB2 0RE, England

来源：

LANCET ONCOLOGY | 2011年 / 12卷 / 12期

关键词：

CHRONIC MYELOID-LEUKEMIA; LUNG-CANCER; PROMOTER HYPERMETHYLATION; PANCREATIC-CANCER; SPORADIC BREAST; MUTATIONS; TUMORS; BRCA1; CARCINOMA; CISPLATIN;

D O I：

10.1016/S1470-2045(11)70123-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

High-grade serous ovarian cancers account for most ovarian-cancer mortality. Although this disease initially responds well to platinum-based chemotherapy, relapse and progression to chemotherapy resistance are frequently seen. Time to relapse after first-line therapy is a predictor of response to secondary platinum treatment: more than 12 months is associated with high chance of a secondary response, whereas relapses within 6 months generally indicate platinum resistance. In this Personal View we discuss whether patterns of response, relapse, and the development of drug resistance in high-grade serous ovarian cancers are related to distinct underlying molecular and cellular biological characteristics. In particular, we propose that rapid relapse with platinum-resistant disease is due to minor subpopulations of intrinsically resistant cancer cells at presentation.

引用

页码：1169 / 1174

页数：6

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