Peptide deformylase inhibitors with activity against respiratory tract pathogens

被引：17

作者：

East, SP ^{[1
]}

Beckett, RP ^{[1
]}

Brookings, DC ^{[1
]}

Clements, JM ^{[1
]}

Doel, S ^{[1
]}

Keavey, K ^{[1
]}

Pain, G ^{[1
]}

Smith, HK ^{[1
]}

Thomas, W ^{[1
]}

Thompson, AJ ^{[1
]}

Todd, RS ^{[1
]}

Whittaker, M ^{[1
]}

机构：

[1] British Biotech Pharmaceut Ltd, Oxford OX4 6LY, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 01期

关键词：

peptide deformylase; inhibitors; antibacterial;

D O I：

10.1016/j.bmcl.2003.10.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3' amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：59 / 62

页数：4

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