ViPR: an open bioinformatics database and analysis resource for virology research

被引：491

作者：

Pickett, Brett E. ^{[1
]}

Sadat, Eva L. ^{[1
]}

Zhang, Yun ^{[1
]}

Noronha, Jyothi M. ^{[1
]}

Squires, R. Burke ^{[1
]}

Hunt, Victoria ^{[1
]}

Liu, Mengya ^{[2
]}

Kumar, Sanjeev ^{[3
]}

Zaremba, Sam ^{[3
]}

Gu, Zhiping ^{[3
]}

Zhou, Liwei ^{[3
]}

Larson, Christopher N. ^{[4
]}

Dietrich, Jonathan ^{[3
]}

Klem, Edward B. ^{[3
]}

Scheuermann, Richard H. ^{[1
,5
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

[2] So Methodist Univ, Dept Stat Sci, Dallas, TX 75275 USA

[3] Northrop Grumman Hlth IT Syst, Rockville, MD 20850 USA

[4] Vecna Technol, Greenbelt, MD 20770 USA

[5] Univ Texas SW Med Ctr Dallas, Div Biomed Informat, Dallas, TX 75390 USA

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / D1期

基金：

美国国家卫生研究院;

关键词：

MULTIPLE SEQUENCE ALIGNMENT; EVOLUTION;

D O I：

10.1093/nar/gkr859

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Virus Pathogen Database and Analysis Resource (ViPR, www.ViPRbrc.org) is an integrated repository of data and analysis tools for multiple virus families, supported by the National Institute of Allergy and Infectious Diseases (NIAID) Bioinformatics Resource Centers (BRC) program. ViPR contains information for human pathogenic viruses belonging to the Arenaviridae, Bunyaviridae, Caliciviridae, Coronaviridae, Flaviviridae, Filoviridae, Hepeviridae, Herpesviridae, Paramyxoviridae, Picornaviridae, Poxviridae, Reoviridae, Rhabdoviridae and Togaviridae families, with plans to support additional virus families in the future. ViPR captures various types of information, including sequence records, gene and protein annotations, 3D protein structures, immune epitope locations, clinical and surveillance metadata and novel data derived from comparative genomics analysis. Analytical and visualization tools for metadata-driven statistical sequence analysis, multiple sequence alignment, phylogenetic tree construction, BLAST comparison and sequence variation determination are also provided. Data filtering and analysis workflows can be combined and the results saved in personal 'Workbenches' for future use. ViPR tools and data are available without charge as a service to the virology research community to help facilitate the development of diagnostics, prophylactics and therapeutics for priority pathogens and other viruses.

引用

页码：D593 / D598

页数：6

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