Mining the plasma proteome for cancer biomarkers

被引：657

作者：

Hanash, Samir M. ^{[1
]}

Pitteri, Sharon J. ^{[1
]}

Faca, Vitor M. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

NATURE | 2008年 / 452卷 / 7187期

关键词：

D O I：

10.1038/nature06916

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Systematic searches for plasma proteins that are biological indicators, or biomarkers, for cancer are underway. The difficulties caused by the complexity of biological- fluid proteomes and tissue proteomes ( which contribute proteins to plasma) and by the extensive heterogeneity among diseases, subjects and levels of sample procurement are gradually being overcome. This is being achieved through rigorous experimental design and in- depth quantitative studies. The expected outcome is the development of panels of biomarkers that will allow early detection of cancer and prediction of the probable response to therapy. Achieving these objectives requires high- quality specimens with well- matched controls, reagent resources, and an efficient process to confirm discoveries through independent validation studies.

引用

页码：571 / 579

页数：9

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