Abnormal Brain Structure Implicated in Stimulant Drug Addiction

被引：407

作者：

Ersche, Karen D. ^{[1
,2
,3
]}

Jones, P. Simon ^{[1
,2
,3
]}

Williams, Guy B. ^{[1
,2
,3
,4
]}

Turton, Abigail J. ^{[1
,2
,3
]}

Robbins, Trevor W. ^{[1
,2
,3
]}

Bullmore, Edward T. ^{[1
,2
,3
,5
,6
]}

机构：

[1] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

[2] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

[3] Univ Cambridge, Dept Psychiat, Cambridge CB2 3EB, England

[4] Univ Cambridge, Wolfson Brain Imaging Ctr, Dept Clin Neurosci, Cambridge CB2 0QQ, England

[5] GlaxoSmithKline Inc, Clin Unit Cambridge, Addenbrookes Ctr Clin Invest, Cambridge CB2 2GG, England

[6] Natl Hlth Serv Trust, Cambridgeshire & Peterborough Fdn, Cambridge CB21 5EF, England

来源：

SCIENCE | 2012年 / 335卷 / 6068期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

SUBSTANCE USE DISORDERS; BASAL GANGLIA; RESPONSE-INHIBITION; COCAINE DEPENDENCE; PREFRONTAL CORTEX; TEMPORAL-LOBE; IMPULSIVITY; MEMORY; REINFORCEMENT; SYSTEMS;

D O I：

10.1126/science.1214463

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Addiction to drugs is a major contemporary public health issue, characterized by maladaptive behavior to obtain and consume an increasing amount of drugs at the expense of the individual's health and social and personal life. We discovered abnormalities in fronto-striatal brain systems implicated in self-control in both stimulant-dependent individuals and their biological siblings who have no history of chronic drug abuse; these findings support the idea of an underlying neurocognitive endophenotype for stimulant drug addiction.

引用

页码：601 / 604

页数：4

共 29 条

[1] Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI
Aron, Adam R.
Behrens, Tim E.
Smith, Steve
Frank, Michael J.
Poldrack, Russell A.
[J]. JOURNAL OF NEUROSCIENCE, 2007, 27 (14) : 3743 - 3752
[2] Parallel and interactive learning processes within the basal ganglia: Relevance for the understanding of addiction
Belin, David
Jonkman, Sietse
Dickinson, Anthony
Robbins, Trevor W.
Everitt, Barry J.
[J]. BEHAVIOURAL BRAIN RESEARCH, 2009, 199 (01) : 89 - 102
[3] Acute effects of cocaine on human brain activity and emotion
Breiter, HC
Gollub, RL
Weisskoff, RM
Kennedy, DN
Makris, N
Berke, JD
Goodman, JM
Kantor, HL
Gastfriend, DR
Riorden, JP
Mathew, RT
Rosen, BR
Hyman, SE
[J]. NEURON, 1997, 19 (03) : 591 - 611
[4] Neurobiology of the Adolescent Brain and Behavior: Implications for Substance Use Disorders
Casey, B. J.
Jones, Rebecca M.
[J]. JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 2010, 49 (12) : 1189 - 1201
[5] Nucleus Accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Dalley, Jeffrey W.
Fryer, Tim D.
Brichard, Laurent
Robinson, Emma S. J.
Theobald, David E. H.
Laeaene, Kristjan
Pena, Yolanda
Murphy, Emily R.
Shah, Yasmene
Probst, Katrin
Abakumova, Irina
Aigbirhio, Franklin I.
Richards, Hugh K.
Hong, Young
Baron, Jean-Claude
Everitt, Barry J.
Robbins, Trevor W.
[J]. SCIENCE, 2007, 315 (5816) : 1267 - 1270
[6] Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence
Ersche, Karen D.
Barnes, Anna
Jones, P. Simon
Morein-Zamir, Sharon
Robbins, Trevor W.
Bullmore, Edward T.
[J]. BRAIN, 2011, 134 : 2013 - 2024
[7] Drug Addiction Endophenotypes: Impulsive Versus Sensation-Seeking Personality Traits
Ersche, Karen D.
Turton, Abigail J.
Pradhan, Shachi
Bullmore, Edward T.
Robbins, Trevor W.
[J]. BIOLOGICAL PSYCHIATRY, 2010, 68 (08) : 770 - 773
[8] Neural systems of reinforcement for drug addiction: from actions to habits to compulsion
Everitt, BJ
Robbins, TW
[J]. NATURE NEUROSCIENCE, 2005, 8 (11) : 1481 - 1489
[9] Individual differences in prefrontal cortex function and the transition from drug use to drug dependence
George, Olivier
Koob, George F.
[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2010, 35 (02) : 232 - 247
[10] The endophenotype concept in psychiatry: Etymology and strategic intentions
Gottesman, II
Gould, TD
[J]. AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (04) : 636 - 645

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