Formation of glucoraphanin by chemoselective oxidation of natural glucoerucin: A chemoenzymatic route to sulforaphane

被引：71

作者：

Iori, R

Bernardi, R

Gueyrard, D

Rollin, P

Polmieri, S

机构：

[1] MIPA, Ist Sperimentale Colture Ind, I-40129 Bologna, Italy

[2] Univ Orleans, Inst Chim Organ & Analyt, F-45067 Orleans 2, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(99)00136-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new semi-synthetic way to produce glucoraphanin (2), the bio-precursor of the potential anticarcinogen sulforaphane (3), has been developed. Starting from glucoerucin (1), isolated from ripe seeds of Eruca sativa, glucoraphanin was obtained through chemoselective oxidation. Controlled myrosinase-catalysed hydrolysis of this precursor quantitatively afforded sulforaphane. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1047 / 1048

页数：2

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