Putting the brake on inflammatory responses: the role of glucocorticoids

被引：46

作者：

Hermoso, M

Cidlowski, J

机构：

[1] NIEHS, Lab Signal Transduct, Res Triangle Pk, NC 27709 USA

[2] NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

来源：

IUBMB LIFE | 2003年 / 55卷 / 09期

关键词：

glucocorticoids (GC); glucocorticoid receptor (GR); nuclear factor kappa B (NF kappa B); activator protein-1 (AP-1); Toll-like receptors (TLRs);

D O I：

10.1080/15216540310001642072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glucocorticoids are among the most widely used agents for the treatment of inflammatory diseases. The primary mechanism of glucocorticoid action is via the glucocorticoid receptor (GR), which blocks the expression of proinflammatory cytokines and adhesion molecules. Repression of many pro-inflammatory genes occurs by inhibition of transcription factors including nuclear factor kappaB (NFkappaB) and activator protein-1 (AP-1). In this article, we discuss the physiological and molecular interaction that occurs between GR and proinflammatory cytokines signaling pathways.

引用

页码：497 / 504

页数：8

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[1] Functional diversity of helper T lymphocytes [J].