A bursting mechanism of chattering neurons based on Ca2+-dependent cationic currents

被引：7

作者：

Aoyagi, T ^{[1
]}

Terada, N

Kang, Y

Kaneko, T

Fukai, T

机构：

[1] Kyoto Univ, Grad Sch Informat, Dept Appl Anal & Complex Dynam Syst, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Informat, Dept Appl Math & Phys, Kyoto 6068501, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Physiol, Kyoto 6068501, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Morphol Brain Sci, Kyoto 6068501, Japan

[5] Tamagawa Univ, Dept Informat Commun Engn, Tokyo 1948610, Japan

[6] CREST, JST, Yokohama, Kanagawa, Japan

来源：

NEUROCOMPUTING | 2001年 / 38卷

关键词：

cation channel; fast rhythmic burst; depolarizing afterpotential (DAP); chattering behavior; gamma frequency band;

D O I：

10.1016/S0925-2312(01)00540-9

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

We propose an ionic conductance model that simulates fast rhythmic bursts in a single compartment neuron. In this modeling, the essential point is that Ca2+-dependent cationic current, whose reversal potential is approximately -45 mV,plays a key role for generating the depolarizing afterpotential (DAP) and the doublet/triplet firing. For the calcium dynamics, the kinetics of the extrusion and the chelation of intracellular free Ca2+ with Ca2+-pump and buffering proteins is taken into account. The resulting model quite accurately predicts the experimentally observed natural pattern of the chattering behavior. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：93 / 98

页数：6

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