Acute actions of thyroid hormone on blood vessel biochemistry and physiology

被引：14

作者：

Barreto-Chaves, Maria Luiza ^{[1
]}

Monteiro, Priscilla de Souza ^{[1
]}

Fuerstenau, Cristina R. ^{[1
]}

机构：

[1] Univ Sao Paulo, Lab Biol Celular & Anat Func, Inst Ciencias Biomed, Dept Anat, BR-05508900 Sao Paulo, Brazil

来源：

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY | 2011年 / 18卷 / 05期

关键词：

endothelium; systemic vascular resistance; thyroid hormones; vascular smooth muscle cells; VASCULAR SMOOTH-MUSCLE; NONGENOMIC ACTIONS; RESISTANCE ARTERIES; DIFFERENT PHASES; CORONARY-ARTERY; CEREBRAL-CORTEX; HYPERTHYROIDISM; TRIIODOTHYRONINE; DISEASE; HEART;

D O I：

10.1097/MED.0b013e32834a785c

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Purpose of review Description of the progress about the vascular effects promoted by thyroid hormones. Recent findings Over the past few years, a number of studies have shown that in addition to genomic effects on blood vessels, thyroid hormones exert extranuclear nongenomic effects on vascular smooth muscle cells and endothelium. These nongenomic effects occur rapidly and do not involve thyroid hormone response elements-mediated transcriptional events. In this context, the genomic and nongenomic events promoted by thyroid hormones act in concert to control the vascular hemodynamic and regulate the cardiovascular function. Summary Considering the antiatherogenic property of thyroid hormones and the rapid effects produced by this molecule as a vasodilator, including that in the coronary bed, a better understanding of the molecular mechanisms involved in its action may contribute to the development of drugs that can be clinically used to increase the known benefits promoted by thyroid hormones in cardiovascular physiology.

引用

页码：300 / 303

页数：4

共 35 条

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