Emerging role of long noncoding RNAs in autoimmune diseases

被引：349

作者：

Wu, Guo-Cui ^{[1
,2
]}

Pan, Hai-Feng ^{[1
,2
]}

Leng, Rui-Xue ^{[1
,2
]}

Wang, De-Guang ^{[3
]}

Li, Xiang-Pei ^{[4
]}

Li, Xiao-Mei ^{[4
]}

Ye, Dong-Qing ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Anhui Prov Lab Populat Hlth & Major Dis Screening, Hefei 230032, Anhui, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 2, Dept Nephrol, Hefei 230601, Anhui, Peoples R China

[4] Anhui Med Univ, Anhui Prov Hosp, Dept Rheumatol & Immunol, Hefei 230001, Anhui, Peoples R China

来源：

AUTOIMMUNITY REVIEWS | 2015年 / 14卷 / 09期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

lncRNA; Noncoding RNA; Immune function; Autoimmunity; Autoimmune disease; GROWTH-ARREST; RHEUMATOID-ARTHRITIS; CELL-PROLIFERATION; PROMOTER REGION; GENE-EXPRESSION; DENDRITIC CELLS; CANDIDATE GENE; PSORIASIS; SUSCEPTIBILITY; DIFFERENTIATION;

D O I：

10.1016/j.autrev.2015.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Long noncoding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of noncoding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression of lncRNAs in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), multiple sclerosis (MS), autoimmune thyroid disease (AITD), psoriasis, polymyositis/dermatomyositis (PM/DM) and Crohn's disease (CD). (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：798 / 805

页数：8

共 93 条

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